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. 2017 Jul 11;7:5127. doi: 10.1038/s41598-017-05430-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of p75^ECD in urine between different groups and ALS Diagnostic Grades: (A) Urine p75^ECD in ALS was higher than OND and CTRL by one way ANOVA (p < 0.001). (B) Urine p75^ECD in ALS (onset less than 6 months) was higher than OND and CTRL by one way ANOVA (p < 0.001). (C) Urine p75^ECD was different among three ALS diagnosis grades (p < 0.001), and the rank test among them suggests that urine p75^ECD increased with ALS diagnostic degree (p < 0.001).