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. 2017 Jul 11;7:5127. doi: 10.1038/s41598-017-05430-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Urine p75^ECD levels and ALS-severity and progression. (A) There was significant difference among three clinical stages; (B) There were no differences in urine p75^ECD concentrations among ALS patients with different onset regions; (C) There was negative correlation between baseline p75^ECD and ALSFRS-r scores in ALS patients; (D) Significantly higher urine p75^ECD concentrations were detected in the fast-progression group than in the slow-progression group.