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. 2016 Aug 18;59(11):2393–2405. doi: 10.1007/s00125-016-4074-5

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — DNA methylation landscape in insulin-resistant vs insulin-sensitive women in SAT (a, d), VAT (b, e) and PBMCs (c, f). Based on Illumina annotation, 112,057 (SAT), 124,089 (VAT) and 99,462 (PBMCs) CpG probes were mapped to genome regions. We calculated the average level of DNA methylation within each of the insulin-resistant (black bars) and insulin-sensitive (white bars) groups stratified on genome region in relation to functional gene regions (a, b, d) and CpG content (d, e, f). TSS1500, within 1500 bp of transcriptional start site (TSS); TSS200, within 200 bp of TSS. Genome locations: Island, CpG island; N_Shelf, upstream CpG island shelf; N_Shore, upstream CpG island shore; S_Shore, downstream CpG island shore; S_Shelf, downstream CpG island shelf; Open_sea; other CpG regions