Table 2.

Over-representation of specific gene-sets among differentially expressed genes in SAT between insulin-resistant and insulin-sensitive women^a

Pathwayc	Observedb	Expectedb	Adjusted p value
TRAIL signalling pathway	73	49	0.0024
Signalling events mediated by VEGFR1 and VEGFR2	70	48	0.0024
GMCSF-mediated signalling events	70	48	0.0024
IL3-mediated signalling events	70	48	0.0024
PAR1-mediated thrombin signalling events	70	48	0.0024
S1P1 pathway	70	47	0.0024
IFN-γ pathway	70	48	0.0024
ErbB1 downstream signalling	70	47	0.0024
β1 integrin cell surface interactions	78	50	0.0024
Urokinase-type plasminogen activator and uPAR-mediated signalling	70	47	0.0024
Plasma membrane oestrogen receptor signalling	71	48	0.0024
IGF1 pathway	70	47	0.0024
Insulin pathway	70	47	0.0024
Arf6 signalling events	70	47	0.0024

^aWebgestalt was used to identify over-represented gene-sets (Pathway commons) among 647 differentially expressed genes as compared with all 11,722 analysed genes using default settings

^bNumber of differentially expressed genes

Arf6, ADP-ribosylation factor 6; ErbB1, epidermal growth factor receptor; GMCSF, granulocyte-macrophage colony-stimulating factor; PAR1, proteinase-activated receptor 1; S1P1, sphingosine-1-phosphate receptor; uPAR, plasminogen activated receptor urokinase type