Table 5.

Differentially expressed insulin signalling pathway genes accompanied by DMS in SAT between insulin-resistant and insulin-sensitive women^a

Probe	Gene	Relation to gene region	DNA methylation				Gene expression
			IR	IS	IR − IS	p value	IS	IR/IS	p value
cg17133045	AKT3	Body	0.761 (0.047)	0.735 (0.051)	0.026	0.007	144	0.92	4.38 × 10−3
cg04221461	AKT3	Body	0.524 (0.070)	0.490 (0.043)	0.034	0.002	144	0.92	4.38 × 10−3
cg08428486	BRAF	Body	0.807 (0.122)	0.833 (0.035)	−0.026	0.048	235	0.92	3.96 × 10−4
cg25204078	BRAF	TSS1500	0.771 (0.040)	0.757 (0.042)	0.014	0.034	235	0.92	3.96 × 10−4
cg06748146	HK1	Body	0.734 (0.047)	0.709 (0.044)	0.026	0.007	170	1.09	3.07 × 10−3
cg05514401	IRS2	1st exon	0.823 (0.065)	0.792 (0.048)	0.031	0.002	242	0.85	1.24 × 10−3
cg18932526	MAPK8	TSS1500	0.907 (0.099)	0.929 (0.020)	−0.022	0.020	73	0.94	3.47 × 10−3
cg19612574	MAPK8	TSS1500	0.935 (0.074)	0.950 (0.019)	−0.015	0.022	73	0.94	3.47 × 10−3
cg20994699	PDX103A	Body	0.572 (0.092)	0.544 (0.086)	0.028	0.048	100	0.82	4.48 × 10−4
cg03465562	PHKA2	Body	0.929 (0.092)	0.953 (0.019)	−0.024	0.021	167	0.91	9.80 × 10−4

DNA methylation data are expressed as average (SD); gene expression data are expressed as average

IR, insulin-resistant; IS, insulin-sensitive; TSS1500, within 1500 bp of transcriptional start site