Table 6.
Differentially expressed genes accompanied by DMS in VAT between insulin-resistant and insulin-sensitive womena
| Probe | Gene | Relation to gene region | DNA methylation | Gene expression | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| IR | IS | IR − IS | p value | IS | IR/IS | p value | |||||
| cg17174775 | AASS | TSS1500 | 0.016 | 0.039 | 0.027 | 0.033 | −0.011 | 0.0022 | 118 | 0.88 | 0.000121 |
| cg09711028 | ABCC9 | Body | 0.913 | 0.041 | 0.897 | 0.046 | 0.016 | 0.033 | 391 | 0.86 | 0.000303 |
| cg16236108 | AGPAT9 | TSS200 | 0.062 | 0.042 | 0.076 | 0.04 | −0.014 | 0.027 | 89 | 0.78 | 7.62 × 10−6 |
| cg14229247b | ANP32B | TSS1500 | 0.04 | 0.048 | 0.048 | 0.046 | −0.009 | 0.038 | 237 | 0.91 | 3.61 × 10−5 |
| cg08400424b | ARHGAP26 | Body | 0.55 | 0.1 | 0.597 | 0.103 | −0.047 | 0.028 | 109 | 1.16 | 2.33 × 10−5 |
| cg05185926 | ARHGAP26 | 3′UTR | 0.712 | 0.101 | 0.75 | 0.121 | −0.038 | 0.025 | 109 | 1.16 | 2.33 × 10−5 |
| cg11796181b | ARHGAP26 | Body | 0.754 | 0.043 | 0.708 | 0.047 | 0.046 | 0.00017 | 109 | 1.16 | 2.33 × 10−5 |
| cg12264626 | CA3 | TSS1500 | 0.183 | 0.054 | 0.162 | 0.095 | 0.021 | 0.036 | 242 | 0.45 | 0.000136 |
| cg00908631 | CDKN2C | TSS1500 | 0.668 | 0.052 | 0.632 | 0.06 | 0.036 | 0.0011 | 134 | 0.82 | 0.000184 |
| cg10156302 | DAPK2 | Body | 0.605 | 0.091 | 0.552 | 0.111 | 0.053 | 0.01 | 171 | 0.86 | 0.000235 |
| cg23165541 | DAPK2 | 5′UTR | 0.403 | 0.094 | 0.363 | 0.09 | 0.039 | 0.014 | 171 | 0.86 | 0.000235 |
| cg06904649 | DAPK2 | Body | 0.767 | 0.037 | 0.744 | 0.043 | 0.022 | 0.043 | 171 | 0.86 | 0.000235 |
| cg16151151 | ISL1 | Body | 0.196 | 0.069 | 0.172 | 0.095 | 0.024 | 0.016 | 99 | 0.8 | 0.000045 |
| cg17686487 | ISL1 | Body | 0.434 | 0.082 | 0.395 | 0.089 | 0.039 | 0.012 | 99 | 0.8 | 0.000045 |
| cg16270526 | ISL1 | Body | 0.225 | 0.069 | 0.185 | 0.077 | 0.04 | 0.023 | 99 | 0.8 | 0.000045 |
| cg26422022 | LOX | TSS200 | 0.032 | 0.039 | 0.039 | 0.036 | −0.007 | 0.040419 | 169 | 1.22 | 9.74 × 10−5 |
| cg22836153 | LOX | Body | 0.057 | 0.038 | 0.065 | 0.033 | −0.008 | 0.042 | 169 | 1.22 | 9.74 × 10−5 |
| cg03422350 | MOCS1 | Body | 0.722 | 0.068 | 0.68 | 0.071 | 0.042 | 0.031 | 205 | 0.79 | 9.42 × 10−5 |
| cg10791278 | MOCS1 | Body | 0.782 | 0.056 | 0.737 | 0.061 | 0.045 | 0.0016 | 205 | 0.79 | 9.42 × 10−5 |
| cg06023702 | PAIP2B | TSS200 | 0.029 | 0.043 | 0.04 | 0.041 | −0.011 | 0.018 | 114 | 0.85 | 5.02 × 10−5 |
| cg06241044 | PAIP2B | 5′UTR | 0.265 | 0.052 | 0.242 | 0.066 | 0.023 | 0.038 | 114 | 0.85 | 5.02 × 10−5 |
| cg22999327 | PDE3A | Body | 0.53 | 0.105 | 0.485 | 0.124 | 0.045 | 0.028 | 133 | 0.82 | 1.19 × 10−5 |
| cg02631767 | PDE3A | Body | 0.875 | 0.056 | 0.857 | 0.058 | 0.018 | 0.048 | 133 | 0.82 | 1.19 × 10−5 |
| cg04857033 | PHGDH | Body | 0.376 | 0.078 | 0.336 | 0.089 | 0.04 | 0.049 | 135 | 0.88 | 0.00039 |
| cg26166935 | PHLPP1 | Body | 0.857 | 0.039 | 0.837 | 0.037 | 0.02 | 0.03 | 101 | 0.91 | 0.000203 |
| cg03299121 | PNO1 | TSS200 | 0.055 | 0.044 | 0.064 | 0.041 | −0.01 | 0.0003 | 53 | 1.08 | 0.000385 |
| cg06123940 | RNF125 | TSS1500 | 0.798 | 0.044 | 0.785 | 0.043 | 0.012 | 0.029 | 109 | 0.88 | 0.0004 |
| cg18101249 | RNF125 | Body | 0.082 | 0.049 | 0.089 | 0.037 | −0.006 | 0.046 | 109 | 0.88 | 0.0004 |
| cg13849419 | TJP2 | Body | 0.509 | 0.095 | 0.468 | 0.106 | 0.041 | 0.043 | 179 | 0.93 | 0.000239 |
DNA methylation data are expressed as average (SD); gene expression data are expressed as average
aDifferentially expressed genes (10% FDR) accompanied by DMS (p < 0.05) in VAT between insulin-resistant and insulin-sensitive women. Groups were compared using Limma and adjusting for BMI (gene expression, DMS) and age (DMS)
bDMS and differentially expressed gene common to SAT and VAT