Table 1. Empiric choice of antibiotics for CAP.

Setting	Route	<65 years old, no antibiotics within 90 days and no comorbidities	≥65 years, antibiotics with 90 days or comorbidity*	Alternative
Outpatient	PO	Amoxicillin	Amoxicillin-clavulanate or a second generation cephalosporin	Moxifloxacin or levofloxacin
Inpatients (non-severe)	PO/IV	Ampicillin	Amoxicillin-clavulanate or cefuroxime or a third generation cephalosporin	Moxifloxacin or levofloxacin
Inpatients (severe/ICU)	IV	Amoxicillin-clavulanate or cefuroxime or a third generation cephalosporin plus a macrolide/azalide	Amoxicillin-clavulanate or cefuroxime or a third generation cephalosporin plus a macrolide/azalide	Moxifloxacin or levofloxacin plus amoxicillin-clavulanate or cefuroxime or a third generation cephalosporin

*, cardiovascular disease, chronic respiratory disease, chronic renal failure, diabetes mellitus, HIV infection. CAP, community-acquired pneumonia.