Table 1.

Superiority of the F1 over the NH36 antigen in interferon (IFN)-γ and tumor necrosis factor alpha (TNF-α)/interleukin (IL)-10 ratios.

Antigens	F1				NH36
Patients	Endemic controls (EC)	Asym.a	Cured cutaneous leishmaniasis (CCL)	CVL	EC	Asym.	CCL	CVL
IFN-γ (pg/ml)	58	147	195	231	37	126	156	135
TNF-α (pg/ml)	451	448	357	906	232	254	285	516
IL-10 (pg/ml)	117	109	114	141	94	102	101	140
IFN-γ/IL-10 ratio	0.5	1.3	1.7	1.6	0.4	1.2	1.6	1
TNF-α/IL-10 ratio	3.9	4.1	3.1	6.4	2.4	2.5	2.8	3.7
IFN-γ/IL-10 ratio % enrichment	20	8	6	38	–	–	–	–
TNF-α/IL-10 ratio % enrichment	38	39	10	42	–	–	–	–

Calculation was performed according to the following equation = (F1-NH36/F1) values × 100 = protective increment. doi: 10.1371/journal.pntd.0000866.t003.

^aAsymptomatic.