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. Author manuscript; available in PMC: 2017 Jul 12.
Published in final edited form as: J Am Chem Soc. 2017 Feb 9;139(7):2741–2749. doi: 10.1021/jacs.6b12236

Figure 3.

Figure 3

(A) Linear correlation (R2 = 0.9947) was determined between the number of spiked and captured PC3 cells with NP-HBCTC-Chip, with cancer cell lines spiked into whole blood at a concentration of 10, 50, 100, 200, 500, and 1000 (n = 3 for each condition). (B) Chip capture performance for ultralow concentrations of cancer cells (5 cells/mL of whole blood, n = 10). Each data point indicates the capture efficiency of an independent experiment for MB-MDA-231 and PC3 cells. Cell capture efficiency at such low cancer cell concentrations varied from 0 to 100%. For spiking concentrations of 1000, 500, and 200 cells per mL, a serial dilution of an initial 100 000 cells/mL was used. A micromanipulator equipped with a microneedle was used for spiking concentrations of 100, 50, 10, and 5 cancer cells/mL of whole blood.