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. 2017 Jul 12;11:402. doi: 10.3389/fnins.2017.00402

Figure 1.

Figure 1

Transmission electron microscopy of sural nerves and HSPB8 transfected SH-SY5Y cells. (A) Sural nerves from a CMT2L patient. Arrow shows the abnormal mitochondrial membranes, aggregated, small, round mitochondria. (B) Sural nerves from diabet patient. (C) SH-SY5Y cells expressing WT HSPB8 have normal mitochondrial distribution with a discrete appearance that was diffuse throughout the cell. (D) SH-SY5Y cells expressing K141N HSPB8 show aggregated mitochondria in either one or two large clusters, as shown by the arrow. The arrowhead shows cellular regions devoid of mitochondria. (E) Higher magnification of aggregated mitochondria of (D) shows apparently aggregates of individual mitochondria. Scale bars (A,B): 1, 2, and 0.5 μm respectively, (C–E): 2, 2, and 1 μm respectively.