Table 2.

Overlap with previous studies in aging/longevity transcriptomics

	Hong	Harries	Passtoors	Akker	Peters
Study year	2008	2011	2012	2014	2015
Overlap	100%	100%	98%	65%	73%
Overlap P‐value	3.2 × 10−14	3.8 × 10−51	6.9 × 10−154	<1.0 × 10−300 a	<1.0 × 10−300 a
SRCC	0.73	0.62	0.60	0.44	0.61
Shared genes in top 10	FCGBP LRRN3b NRCAM PDGFRB	ABLIM1 CCR7 CD248 FAM102A LRRN3b NELL2	ABLIM1 CAMK4 CD248 LRRN3b NOG	LRRN3b NELL2	ABLIM1 CD248 FAM102A LRRN3b NELL2

The following publications were used to generate this table: Hong (Hong et al., 2008), Harries (Harries et al., 2011), Passtoors (Passtoors et al., 2012), Akker (Van den Akker et al., 2014), and Peters (Peters et al., 2015). The overlap was calculated based on how many identified genes were significantly regulated and concordant in their regulation direction. Spearman rank correlation coefficient (SRCC) was calculated using all genes identified in the corresponding study. Shared genes in top 10 describes which genes were found in both studies to be among the top 10 most significantly regulated transcripts, ranked by false discovery rate (Van den Akker) or by P‐value (all others).

^aFisher's exact test P‐value could not be calculated (P < 1.0 × 10⁻³⁰⁰).

^b LRRN3 (Leucine Rich Repeat Neuronal 3) was identified as the most significantly regulated gene by all studies including the present one.