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. 2017 May 18;151(4):405–416. doi: 10.1111/imm.12738

Figure 5.

Figure 5

Antiretroviral therapy‐naive HIV‐infection reduces CD39 and CD73 expression in naive and central memory regulatory T (Treg) cells. (a, c, e) Representative dot plots illustrating the gating strategy of CD39 and CD73 expression. The median numbers of each Treg subset expressing CD39, CD73 or both markers are shown in (b), (d) and (f), respectively. The differences between HIV + and HIV – participants were calculated using Mann–Whitney U‐test. Effector and effector memory Treg cells from antiretroviral therapy‐naive HIV‐infected participants showed significant increase in CD39 (P < 0·05) and CD73 (P < 0·001) expression. In contrast, these markers were highly expressed instead on naive (P < 0·05 and P < 0·0001 respectively for CD39 and CD73) and central memory (P < 0·05 for CD73) Treg cells from uninfected individuals. A similar trend was observed for the combined expression of both CD39 and CD73. *P <0·05, **P <0·001, ****P <0·0001.