Skip to main content
. 2017 May 30;16(4):814–824. doi: 10.1111/acel.12619

Figure 1.

Figure 1

ceh‐23 and cep‐1 act in the same genetic pathway to modulate longevity when mitochondrial electron transport chain (ETC) function is impaired. (A) Both ceh‐23 and cep‐1 mutations partially suppressed the extended lifespan of the isp‐1(qm150) mutant (P < 0.0005), and inactivation of ceh‐23 and cep‐1 did not additively suppress isp‐1 mutant lifespan, as the triple mutant lived as long as the double mutants (P = 0.529 compared to cep‐1;isp‐1 and P = 0.003 compared to ceh‐23;isp‐1). Inactivation of ceh‐23 and cep‐1 partially suppressed the long lifespan of the nuo‐6(qm200) mutant (P < 0.0005 and 0.001, respectively) (B) and restored lifespan in the short‐lived gas‐1(fc21) (C) and mev‐1(kn1) (D) mutants (all with P < 0.0005). Survival curves represent data pooled from multiple biological replicates. Quantitative data for the individual and pooled experiments are shown in Table S1 (Supporting information).