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. 2017 Apr 12;16(4):672–682. doi: 10.1111/acel.12595

Figure 1.

Figure 1

RNAi knockdown of 36 of 82 genes in CHARGE gene set increases lifespan at 25 °C. Bars indicate percent change in mean lifespan for RNAi targeting CHARGE genes relative to experiment‐matched EV(RNAi) when experiments were pooled. Error bars are standard error. Blue bars indicate RNAi clones that increased lifespan by our significance criteria. For each Caenorhabditis elegans gene, the table to the left indicates the corresponding human ortholog, the ortholog confidence category (high‐confidence ortholog, HCO; related protein, RP), the life stage at which RNAi was started, and the direction of change in expression of each human gene with age in specified tissues [lymphoblastoid cell line, LCL; peripheral blood mononuclear cell, PBMC; assembled from Peters et al. (2015)].