Figure 8.

Adoptive transfer of TLR4^−/− macrophages attenuated the exacerbation of dextran sulphate sodium (DSS) ‐induced colitis by ficolin‐A (FCN‐A). After macrophage depletion, mice were adoptively transferred with bone‐marrow‐derived macrophages (BMDMs) as described in the Supplementary material (Fig. S6). (a) Body weight, (b) Disease Activity Index (DAI) score, (c) colon length, (d) statistical analysis of histopathological score, and (e) representative data of haematoxylin & eosin (H&E) staining. (f–h) The levels of the interleukin‐1β (IL‐1β), IL‐6 and tumour necrosis factor‐α (TNF‐α) in the homogenate from colonic tissues were detected by ELISA. Six mice were analysed in each group. Values are mean ± SEM from three independent experiments. *P < 0·05.