Fig. 3.

Predicted population mean (black solid lines) and observed (open circles) plasma zidovudine C-T profiles following a 1-hour 2.5 mg/kg i.v. infusion dose (A) (Cload, 1989) (n = 8) or a single 200 mg oral dose (B) (Gallicano et al., 1993) (n = 10) or a single 300 mg oral dose (C) (Anderson et al., 2000) (n = 4) in nonpregnant population. All observed plasma drug concentrations (mean ± S.D.), except one terminal-phase plasma concentration (A), in HIV-infected asymptomatic male volunteers fell within the 90% prediction interval (5th–95th percentile boundaries; lower and upper gray dashed lines, respectively) from a virtual population consisting of 100 male subjects.