Table 3.
Inner retinal layer thicknesses obtained using SS-OCT in normal controls and patients with OTS.
| Regions | OTS | Normal eyes | P values | |||
|---|---|---|---|---|---|---|
| Ipsilateral eyes | Contralateral eyes | Ipsilateral eyes versus normal eyes |
Contralateral eyes versus normal eyes |
|||
| GCC (μm) | ST1 | ∗∗68.1 ± 5.2 (31.0%) | 93.8 ± 6.9 (5.0%) | 98.7 ± 6.6 | <0.001 | 0.191 |
| ST2 | ∗∗68.8 ± 11.6 (35.8%) | 101.1 ± 6.7 (5.6%) | 107.2 ± 7.1 | <0.001 | 0.219 | |
| IT1 | ∗∗74.9 ± 14.8 (33.2%) | 103.8 ± 9.1 (7.4%) | 112.0 ± 6.6 | <0.001 | 0.095 | |
| IT2 | ∗∗70.0 ± 9.1 (25.6%) | 87.9 ± 11.8 (6.6%) | 94.0 ± 7.3 | <0.001 | 0.260 | |
| SN1 | ∗∗88.0 ± 8.4 (24.5%) | ∗∗93.5 ± 12.0 (19.8%) | 116.5 ± 9.0 | <0.001 | <0.001 | |
| SN2 | ∗107.3 ± 6.7 (10.3%) | ∗∗78.0 ± 19.4 (34.8%) | 119.6 ± 8.3 | 0.026 | <0.001 | |
| IN1 | ∗∗105.8 ± 10.6 (13.1%) | ∗∗83.9 ± 16.7 (31.0%) | 121.6 ± 7.7 | 0.002 | <0.001 | |
| IN2 | ∗∗86.0 ± 13.1 (24.8%) | ∗∗93.5 ± 13.3 (18.2%) | 114.3 ± 11.7 | <0.001 | 0.001 | |
| T | ∗∗71.8 ± 13.2 (34.5%) | 102.4 ± 7.6 (6.5%) | 109.6 ± 6.6 | <0.001 | 0.110 | |
| N | ∗∗106.5 ± 8.5 (11.7%) | ∗∗80.9 ± 18.0 (32.9%) | 120.6 ± 7.8 | <0.001 | 0.006 | |
|
| ||||||
| GCL + IPL (μm) | ST1 | ∗∗49.5 ± 6.6 (20.4%) | 59.5 ± 3.7 (4.3%) | 62.2 ± 5.8 | <0.001 | 0.714 |
| ST2 | ∗∗57.0 ± 7.7 (31.6%) | 78.4 ± 4.7 (6.0%) | 83.4 ± 6.5 | <0.001 | 0.199 | |
| IT1 | ∗∗61.1 ± 8.7 (27.7%) | 79.0 ± 6.1 (6.5%) | 84.5 ± 6.0 | <0.001 | 0.138 | |
| IT2 | 50.0 ± 4.7 (8.4%) | 52.6 ± 5.5 (3.6%) | 54.6 ± 6.9 | 0.241 | 1.000 | |
| SN1 | 57.3 ± 5.4 (7.3%) | ∗∗47.1 ± 6.4 (23.7%) | 61.8 ± 4.7 | 0.115 | <0.001 | |
| SN2 | 80.9 ± 5.9 (6.5%) | ∗∗55.4 ± 15.0 (36.0%) | 86.5 ± 6.5 | 0.345 | <0.001 | |
| IN1 | 78.8 ± 7.9 (7.7%) | ∗∗56.0 ± 14.3 (34.3%) | 85.3 ± 6.1 | 0.197 | <0.001 | |
| IN2 | 51.5 ± 4.5 (3.6%) | ∗∗43.0 ± 6.8 (19.5%) | 53.4 ± 5.7 | 1.000 | <0.001 | |
| T | ∗∗59.1 ± 8.1 (29.6%) | 78.7 ± 5.2 (6.3%) | 83.9 ± 6.0 | <0.001 | 0.114 | |
| N | 79.8 ± 6.7 (7.1%) | ∗∗55.7 ± 14.6 (35.2%) | 85.9 ± 6.1 | 0.205 | <0.001 | |
|
| ||||||
| mRNFL (μm) | ST1 | ∗∗18.5 ± 8.3 (49.6%) | 34.6 ± 5.0 (5.7%) | 36.7 ± 3.1 | <0.001 | 0.602 |
| ST2 | ∗∗11.8 ± 6.5 (51.6%) | 22.6 ± 3.8 (6.9%) | 24.3 ± 2.5 | <0.001 | 0.905 | |
| IT1 | ∗∗13.5 ± 7.1 (50.2%) | 24.9 ± 4.8 (8.2%) | 27.1 ± 2.4 | <0.001 | 0.586 | |
| IT2 | ∗∗19.9 ± 10.1 (49.4%) | 35.4 ± 7.1 (9.9%) | 39.3 ± 3.6 | <0.001 | 0.389 | |
| SN1 | ∗∗31.0 ± 6.0 (42.9%) | ∗46.4 ± 8.7 (14.5%) | 54.3 ± 6.7 | <0.001 | 0.023 | |
| SN2 | ∗∗26.3 ± 1.6 (19.5%) | ∗∗22.8 ± 6.8 (30.3%) | 32.6 ± 3.9 | 0.003 | <0.001 | |
| IN1 | ∗∗27.0 ± 3.1 (25.1%) | ∗∗27.9 ± 3.8 (22.7%) | 36.0 ± 4.2 | <0.001 | <0.001 | |
| IN2 | ∗∗34.5 ± 12.7 (43.5%) | 50.4 ± 14.1 (17.5%) | 61.1 ± 11.2 | <0.001 | 0.120 | |
| T | ∗∗12.6 ± 6.6 (50.9%) | 23.8 ± 3.9 (7.5%) | 25.7 ± 1.8 | <0.001 | 0.383 | |
| N | ∗∗26.6 ± 2.3 (22.5%) | ∗∗25.3 ± 5.0 (26.3%) | 33.0 ± 7.6 | <0.001 | <0.001 | |
SS-OCT: swept-source optical coherence tomography; OTS: optic tract syndrome; GCC: ganglion cell complex; GCL + IPL: ganglon cell layer and inner plexiform layer; mRNFL: macular retinal nerve fiber layer; ST: superotemporal; IT: inferotemporal; SN: superonasal; IN: inferotemporal; T: temporal; N: nasal, ∗P < 0.05, ∗∗P < 0.01: generalized linear mixed model; OTS eyes compared with normal control eyes; (%): percentage of decrease in OTS eyes compared with normal control eyes.