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TcES induce a strong systemic suppressive environment. The TcES treatment reduces lymphocyte proliferation to polyclonal stimuli (a). The TcES treatment reduces lymphocyte proliferation to antigen-specific stimuli. The data shown are representative of 2 independent experiments where n = 6. Statistical significance between groups was determined by two-tailed Student's t-test, ∗∗∗P < 0.001 and ∗P < 0.05.
