Figure 5.

TcES withdrawal reduces treatment efficacy. All treatments started at disease onset (±day 13 PI) and continued until sacrifice (day 27 PI), but the treatment was suspended on day 19 PI (red arrow) for the EAE + TcES-W group. The data shown are representative of 2 independent experiments. Means and SEM were calculated for a group of n = 6 mice. The statistical significance between groups was determined by a two-way ANOVA test of the CDI and AUC, ^∗∗∗P < 0.001 and ^∗∗P < 0.01.