Table 3.

Late TcES administration still arrests EAE development.

Treatment	Resolution (%)	Average grade	Maximum grade	Late CDI	CDI	AUC
EAE + BSA	0%	2 ± 1	3.5	54.5	64	28.5
EAE + TcES	0%	0.6 ± 0.3	1.5	14.5	21.5∗∗∗	9.8∗∗∗
EAE + TcES-L	0%	1.1 ± 0.5	2	28	30∗∗∗	16.8∗∗

Resolution = percentage of mice in which disease resolved completely; average grade = average grade of disease of each group; maximum grade = the peak clinical score for each group; late CDI = CDI calculated from treatment onset (day 18) until sacrifice (day 26). CDI: cumulative disease index (calculated as the sum of all grades for each group); AUC: area under the curve. The data shown are representative of 2 independent experiments. Means and SEM were calculated for groups of n = 6 mice. The difference between AUC and CDI were calculated by two-tailed ANOVA test and described by the following criteria: ^∗∗∗P < 0.001 and ^∗∗P < 0.01. All statistical comparisons were made against the group pinpointed by a blue parenthesis.