Table 3.

Size and strength properties of the engineered mice (second cohort). au, arbitrary units; WT, wild type.

Measure	Number of mice per genotype tested or experiments	WT	T991A/+	T991A/T991A	WT versus T991A/+(P)	WT versus T991A/T991A (P)	T991A/+ versus T991A/T991A (P)
Mass (g)	6, 7, and 6	27.1 ±1.9	31.3 ±1.6	22.7 ± .48	0.15	0.14	0.002
Rotarod	7, 7, and 7	169 ± 11	191 ±11	83 ± 6	0.73	0.02	0.0045
12-mm beam (time to cross the beam, s)	6, 7, and 6	6.3 ± 0.95	5 ± 0.3	16.38 ± 1.6	0.73	0.004	0.0005
12-mm beam (paw slips)	6, 7, and 6	0.05 ± 0.06	0.08 ± 0.06	9.9 ± 1.04	0.74	0.0001	0.0001
6-mm beam (failure to cross)	6, 7, and 6	1 of 6 mice in 1 of 3 trials	0	2 of 6 mice in 2 of 3 trials	N/A	N/A	N/A
6-mm beam	6, 7, and 6	6.4 ± 0.33	6.6 ± 0.21	2.1 ± 0.26	0.84	0.0001	0.0001
Grip test by wire	6, 7, and 6	27 ± 4.8	17.3 ± 3.2	38.8 ± 5.6	0.55	0.46	0.07
Force grip test (N/g)	6, 7, and 6	-0.045 ± 0.002	-0.041 ± 0.002	-0.051 ± 0.001	0.85	0.10	0.03