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. Author manuscript; available in PMC: 2017 Nov 23.
Published in final edited form as: Annu Rev Genet. 2016 Oct 10;50:539–570. doi: 10.1146/annurev-genet-121415-122024

Figure 5.

Figure 5

Drosophila central nervous system–derived systemic factors include the Dilps (Drosophila insulin-like peptides), SDR [secreted decoy of insulin receptor (InR)], and GABA (γ-aminobutyric acid). SDR binds to and negatively regulates Dilps. Dilps are secreted from insulin-producing cells (IPCs) and act through InR found in most tissues to regulate growth and metabolism. Note that not all organs on which Dilps act are shown. GABA is produced by the brain to preserve hematopoietic progenitor cells. Data from References 15, 62, 75, 102, 104, 127, 135, 145, and 152.