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. Author manuscript; available in PMC: 2017 Nov 23.
Published in final edited form as: Annu Rev Genet. 2016 Oct 10;50:539–570. doi: 10.1146/annurev-genet-121415-122024

Figure 9.

Figure 9

Muscle-derived Myo (myoglianin) may act through Babo or Wit receptors to decrease fat body nucleolar size and ribosomal RNA and increase life span. ImpL2 is secreted from muscle upon mild mitochondrial dysfunction. Injured imaginal discs secrete Dilp8 (Drosophila insulin-like peptide 8), which acts on Lgr3 (leucine rich repeat–containing G-protein–coupled receptor 3)-positive neurons to inhibit insulin and prothoracicotropic hormone (PTTH) signaling and developmental progression. Also, ImpL2 is secreted by malignant scrib and scrib RasV12 tumor-like larval imaginal discs transplanted to adults. Data from References 26, 27, 32, 41, 48, 49, 108, and 147.