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. 2017 Mar 30;9(1):51–55.

Table I.

Comparing Herceptin form IV and SC

IV SC
Schedule 3-weekly 3-weekly
Vial 150 mg 600 mg
Price of 1 vial 556,02 € 1684,30 €
Weight-based dose calculation Yes No
Loading dose Yes No
- Initial dose 8 mg/kg NA
- Initial infusion time 90 min NA
- Maintenance dose 6 mg/kg NA
- Maintenance infusion time* 30 min NA
Injection time
Observation time after administration
NA 2-5 min
- 1ste dose 6 hours 6 hours
- Subsequent after preparing 2 hours 2 hours
- Stable 48 hours at 2°C-8°C Yes Yes
- Stable 6 hours in daylight (&30°C) NA Yes
Remaining solution should be discarded Yes NA

*If the initial dose was well tolerated than the administration time can be reduced; NA = not applicable