Table I.
IV | SC | ||
Schedule | 3-weekly | 3-weekly | |
Vial | 150 mg | 600 mg | |
Price of 1 vial | 556,02 € | 1684,30 € | |
Weight-based dose calculation | Yes | No | |
Loading dose | Yes | No | |
- Initial dose | 8 mg/kg | NA | |
- Initial infusion time | 90 min | NA | |
- Maintenance dose | 6 mg/kg | NA | |
- Maintenance infusion time* | 30 min | NA | |
Injection time Observation time after administration |
NA | 2-5 min | |
- 1ste dose | 6 hours | 6 hours | |
- Subsequent after preparing | 2 hours | 2 hours | |
- Stable 48 hours at 2°C-8°C | Yes | Yes | |
- Stable 6 hours in daylight (&30°C) | NA | Yes | |
Remaining solution should be discarded | Yes | NA |
*If the initial dose was well tolerated than the administration time can be reduced; NA = not applicable