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. Author manuscript; available in PMC: 2018 Apr 28.
Published in final edited form as: J Med Chem. 2017 Apr 17;60(8):3525–3530. doi: 10.1021/acs.jmedchem.7b00158

Figure 4.

Figure 4

Comparison of KPC-2 active site with the narrow-spectrum β-lactamase, TEM-1 and the extended-spectrum beta-lactamase (ESBL), CTX-M-14. (A) KPC-2 complexed with cefotaxime superimposed onto TEM-1 (KPC-2: white, TEM-1: green, cefotaxime: yellow). (B) KPC-2 complexed with faropenem superimposed onto CTX-M-14 (KPC-2: white, CTX-M-14: green, faropenem: yellow).