Comparison of KPC-2 active site with the narrow-spectrum β-lactamase, TEM-1 and the extended-spectrum beta-lactamase (ESBL), CTX-M-14. (A) KPC-2 complexed with cefotaxime superimposed onto TEM-1 (KPC-2: white, TEM-1: green, cefotaxime: yellow). (B) KPC-2 complexed with faropenem superimposed onto CTX-M-14 (KPC-2: white, CTX-M-14: green, faropenem: yellow).