Skip to main content
. 2016 Oct 5;42(5):989–1000. doi: 10.1038/npp.2016.178

Figure 1.

Figure 1

Short-access cannabinoid self-administration during adolescence improves working memory performance in adulthood. (a) Experimental timeline. Rats (n=12 per group) were trained to self-administer (b) sucrose pellets or (c) WIN55,212-2 (0.0125 mg/kg/infusion). Active lever presses were significantly higher than inactive in every 2-h session for both sucrose and WIN groups. Reinforcers or infusions earned are shown in gray in (b) and (c), respectively. (d) Working memory performance did not differ between self-administration groups during training on 0–12 s delays. (e) Rats with adolescent WIN self-administration experience exhibited better working memory when the delay range was expanded to 0–24 s. The proportion of correct responses for WIN SA rats was greater than sucrose SA controls across many delays with high cognitive load. Values show group means±SEM; IV: intravenous; PD: postnatal day; SA: self-administration; WM: working memory; ***p<0.001.