Table 1.

Retrospective and Randomized data on surgery alone and (neo-) adjuvant RT in ESTS. This table summarizes published data on radiotherapy only with respect to the radical resectability R0, wound complications and local control. The - mark means no data are available on this issue in the full paper. In the nomogram by Cahlon [22], the most unfavorable patient characteristics (for details see text) were chosen. In the study by Yang [24] 141 patients were randomized; 91 with high grade sarcomas and 50 with low grade histologies, 70 received radiotherapy and 71 did not.

Retrospective and Randomized data on Surgery Alone and (neo-) adjuvant RT plus Surgery in ESTS
Author/Reference	n	RT regimen	CT regimen	R0 resections	Wound complications	Local control (@ X years)
Cahlon [22]	684	0 Gy (surgery only)	none	–	–	53% @ 5 yrs
Pisters [19]	88	0 Gy (surgery only)	none	84%	–	84% @ 10 yrs
Baldini [20]	74	0 Gy (surgery only)	none	92%	–	93% @ 10 yrs
Rosenberg [4]	Randomized trial n = 16 versus 27	0 Gy (amputation)	ACM (all cases)	100%	–	100% @ 4.7 yrs
		50 + 10–20 Gy		85%		85% @ 4.7 yrs
Pisters [23]	Randomized trial n = 78 versus 86	0 Gy (surgery only)	none	82%	10%	69% @ 5 yrs
		42 – 46 Gy brachytherapy	none		48% (direct afterloading) 14% (delayed afterloading)	82% @ 5 yrs
Yang [24]	Randomized trial n = 141 (for details see Legend)	0 Gy (surgery only)	Adjuvant 5 times AC for all high grade STS	–	Trial randomized postoperative RT only	In high grade STS 78% versus 100% @ 10 yrs In low grade STS 68% versus 95% @ 10 yrs
		45 + 18 Gy postoperative		–
O’Sullivan [1]	Randomized trial n = 94 versus 96	50 Gy preoperative	none	84%	35%	92% @ 3.3 yrs
		50 + 16 Gy postoperative	none	86%	17%	93% @ 3.3 yrs

Abbreviations: RT = radiotherapy, ESTS = extremity soft tissue sarcoma, n = number of cases, CT = chemotherapy, AC = doxorubicin and cyclophosphamide, ACM = doxorubicin, cyclophosphamide and methotrexate.