Table 2.
Genetic, Obstructive and Toxic/Metabolic Risk Factors for Recurrent/Chronic Pancreatitis Stratified by Patient Age. Data reported as number of patients/number screened (%). Bolded p-value represents statistical significance (p<0.05).
| Genetic Risk Factor | Onset <6 yr | Onset 6–11 yr | Onset ≥12 yr | p-value |
|---|---|---|---|---|
| Genetic mutation (any) | 72/102 (71) | 52/90 (58) | 39/72 (54) | 0.02 |
| PRSS1 | 42/98 (43) | 20/79 (25) | 13/63 (21) | <0.01 |
| CFTR | 27/89 (30) | 23/83 (27) | 24/64 (38) | 0.39 |
| SPINK1 | 12/86 (14) | 22/74 (30) | 6/58 (10) | 0.84 |
| CTRC | 8/56 (14) | 1/51 (2) | 1/43 (2) | 0.01 |
| Family History -Acute Pancreatitis | 39/104 (38) | 27/95 (28) | 18/82 (22) | 0.02 |
| Family History -Chronic Pancreatitis | 36/105 (34) | 20/92 (22) | 14/85 (16) | <0.01 |
| Obstructive Risk Factor | ||||
| Any | 45/128 (38) | 36/110 (33) | 27/102 (26) | 0.16 |
| Pancreas Divisum | 18/125 (14) | 12/107 (11) | 8/99 (8) | 0.14 |
| Sphincter of Oddi dysfunction | 4/122 (3) | 2/104 (2) | 3/98 (3) | 0.99 |
| Gallstones | 7/125 (6) | 3/106 (3) | 7/101 (7) | 0.70 |
| Pancreaticobiliary malunion | 7/124 (6) | 4/107 (4) | 1/100 (1) | 0.06 |
| Biliary cyst | 5/127 (5) | 5/101 (5) | 1/102 (1) | 0.04 |
| Traumatic pancreatic stricture | 1/126 (1) | 1/105 (1) | 0/101 (0) | 0.46 |
| Duodenal diverticulum | 1/126 (1) | 0/107 (0) | 0/101 (0) | 0.26 |
| Annular pancreas | 1/127 (1) | 1/107 (1) | 1/107 (1) | 0.87 |
| Other pancreatic duct obstruction | 3/127 (2) | 2/107 (2) | 0/102 (0) | 0.15 |
| Toxic/Metabolic Risk Factor | ||||
| Alcoholic | 1/129 (1) | 1/110 (1) | 3/101 (3) | 0.18 |
| Active smoker | 1/128 (1) | 0/111 (0) | 1/101 (1) | 0.89 |
| Passive smoking exposure | 9/126 (7) | 8/107 (7) | 9/95 (9) | 0.54 |
| Hypertriglyceridemia | 2/106 (2) | 7/96 (7) | 7/82 (9) | 0.04 |
| Hepatitis | 1/123 (1) | 0/101 (0) | 2/93 (2) | 0.41 |
| Chronic renal failure | 4/117 (3) | 0/101 (0) | 0/86 (0) | 0.02 |
| IBD – Crohn’s disease | 0/123 (0) | 0/101 (0) | 1/94 (1) | 0.18 |
| IBD – Ulcerative colitis | 0/123 (0) | 0/101 (0) | 3/94 (3) | 0.02 |
| IBD – Indeterminate colitis | 0/123 (0) | 0/101 (0) | 2/94 (2) | 0.06 |
| Autoimmune pancreatitis | 1/90 (1) | 2/89 (2) | 3/76 (4) | 0.23 |
| Other autoimmune diseases | 4/123 (3) | 5/102 (5) | 18/96 (19) | <0.0001 |
| Medication use | 5/110 (5) | 9/99 (9) | 15/88 (17) | <0.01 |
| Azathioprine/6-mercaptopurine | 0/123 (0) | 0/102 (0) | 3/94 (3) | 0.02 |
| Mesalamine | 0/123 (0) | 0/102 (0) | 3/94 (3) | 0.02 |