Table 4.

Disease Burden of Recurrent/Chronic Pancreatitis Stratified by Age of Onset. Data reported as number of patients/number screened (%) or median (25,75 percentile). Bolded p-value represents statistical significance (p<0.05). Cochran-Armitage trend test used to calculate p-value for exocrine insufficiency and diabetes. Jonckheere-Terpstra test used to calculate all other p-values.

Disease Burden	Onset <6 yr	Onset 6–11 yr	Onset ≥12yr	p-value
Exocrine Insufficiency	21/112 (19)	21/98 (21)	10/82 (12)	0.28
Diabetes	2/121 (2)	5/104 (5)	11/92 (12)	<0.01
Pattern of abdominal pain
No abdominal pain	18/108 (16)	8/106 (8)	11/92 (12)	0.09
Usually pain free; episodes of mild-moderate pain	15/108 (14)	12/106 (11)	14/92 (15)
Constant mild-moderate pain	1/108 (1)	10/106 (9)	5/92 (5)
Usually pain free; episodes of severe pain	45/108 (42)	44/106 (42)	23/92 (25)
Constant mild-moderate pain+ episodes of severe pain	25/108 (23)	27/106 (25)	30/92 (33)
Constant severe pain	4/108 (4)	5/106 (5)	9/92 (10)
Average number of ER visits per year – lifelong	1.1 (0,2)	1.5 (0.8,2.5)	1.4 (0.6,2.6)	0.02
Number of ER visits - past year	1 (0,3)	2 (1,3)	2 (1,3)	0.05
Average number of hospitalizations per year – lifelong	0.9 (0,2)	1.3 (0.6,2.4)	1.4 (0.6,2.1)	0.14
Number of hospitalizations - past year	1 (0,2)	1 (1,2)	2 (1,2)	0.09