Table 1. . In vitro competitive assays reveal fitness cost of the RpoB H526D mutant.
Strain mixture |
7H9 broth (CFU/ml) |
Progressive hypoxia (CFU/ml) |
||
---|---|---|---|---|
Day 0 | Stationary phase (day 10) | Day 0 | 7 days after color change (day 21) | |
CDC1551 |
1.2 × 106 |
2.5 × 108 |
7 × 104 |
1.3 × 105 |
rpoB mutant |
2.2 × 106 |
9.4 × 107 |
1.5 × 105 |
6.5 × 104 |
Ratio | 0.70 | -2.4 |