Table 1.
Associations of single nucleotide polymorphisms with presence of AAA.
| Locus | Gene | SNPs | Effect allele | In previous publications
|
In VDB
|
Z test | ||
|---|---|---|---|---|---|---|---|---|
| MAF | OR(95% CI) | MAF | OR(95% CI) | |||||
|
|
|
|
||||||
| P-value | P-value | P-value | ||||||
| 19p13.2 | LDLR | rs6511720 | G | 0.901 | 1.32 (1.20–1.43) [7] | 0.9 | 1.04 (0.89–1.21) | 0.009 |
| Bradley DT, 2013 [7] | 2 × 10^−10 | 0.66 | ||||||
| 12q13.3 | LRP1 | rs1466535 | C | 0.58 | 1.15 (1.10–1.21) [6] | 0.65 | 1.04 (0.94–1.15) | 0.08 |
| Bown MJ, 2011 [6] | 5 × 10^−10 | 0.4 | ||||||
| 9p33.2 | DAB2IP | rs7025846 | A | 0.23 | 1.21 (1.14–1.28) [9] | 0.27 | 1.17 (1.05–1.29) | 0.54 |
| Gretarsdotti, S. 2010 [9] | 5 × 10^−10 | 0.004 | ||||||
| 9p21 | CDKN2A-2B | rs2383207 | T | 0.49 | 1.27 [9] | 0.52 | 1.22 (1.11–1.34) | 0.51 |
| Gretarsdottir S. 2010 [9] | 2 × 10^−8 | 0.0001 | ||||||
| 1p13.3 | SORT1 | rs599839 | G | 0.22 | 0.81 (0.76–0.85) [11] | 0.23 | 0.90 (0.80–1.00) | 0.14 |
| Jones GT, 2013 [11] | 7.2 × 10^−14 | 0.06 | ||||||
MAF: risk allele frequency; OR: odds ratio; CI = confidence interval; LDLR = low density lipoprotein receptor; LRP1 = low density lipoprotein receptor-related protein 1; DAB2IP = DAB2 interacting protein; CDKN2A-2B = Cyclin-dependent kinase inhibitor 2A-2B; SORT1 = Sortilin 1.