Table 2.
Regression coefficients (β) for the association between maternal PFAS serum concentration (ng/mL) and communication development scores in daughters at 15 months of age overall and by mother's age at delivery (< 25 years of age, 25–30 years of age, > 30 years of age).
| Verbal Comprehension | Vocabulary Comprehension and Production | Nonverbal Communication | Social Developmental | |||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | |
| PFOS | ||||||||
| Overalla | 0.03 | (0.01, 0.05)* | 0.02 | (−0.39, 0.44) | 0.02 | (−0.01, 0.05) | 0.02 | (−0.03, 0.08) |
| < 25b | 0.01 | (−0.07, 0.10) | −3.82 | (−6.18, 1.47)* | 0.03 | (−0.10, 0.17) | −0.09 | (−0.34, 0.16) |
| 25–30b | 0.02 | (−0.01, 0.05) | −0.10 | (−0.64, 0.45) | 0.04 | (−0.01, 0.08) | 0.01 | (−0.07, 0.09) |
| > 30b | 0.04 | (0.01, 0.08)* | 0.52 | (−0.02, 1.07) | 0.02 | (−0.02, 0.07) | 0.05 | (−0.02, 0.12) |
| PFOA | ||||||||
| Overalla | 0.24 | (0.12, 0.36) | 0.29 | (−2.07, 2.64) | 0.10 | (−0.07, 0.27) | −0.06 | (−0.36, 0.23) |
| < 25b | 0.20 | (−0.18, 0.58) | −11.39 | (−22.76, −0.02)* | 0.15 | (−0.47, 0.77) | −0.53 | (−1.69, 0.62) |
| 25–30b | 0.15 | (−0.01, 0.31) | 0.38 | (−2.63, 3.39) | 0.12 | (−0.13, 0.37) | −0.06 | (−0.51, 0.39) |
| > 30b | 0.35 | (0.15, 0.55)* | 2.27 | (−0.98, 5.52) | 0.15 | (−0.11, 0.42) | 0.06 | (−0.37, 0.48) |
| PFHxS | ||||||||
| Overalla | 0.03 | (0.00, 0.07) | 0.35 | (−0.32, 1.03) | 0.02 | (−0.03, 0.07) | 0.05 | (−0.04, 0.13) |
| < 25b | 0.06 | (−0.62, 0.73) | −16.26 | (−36.79, 4.27) | 0.29 | (−0.82, 1.39) | 1.02 | (−1.03, 3.07) |
| 25–30b | 0.04 | (0.00, 0.08)* | 0.55 | (−0.21, 1.32) | 0.09 | (0.03, 0.16)* | 0.09 | (−0.02, 0.21) |
| > 30b | 0.01 | (−0.06, 0.07) | 0.17 | (−0.87, 1.21) | −0.06 | (−0.15, 0.02) | −0.02 | (−0.15, 0.12) |
| PFNA | ||||||||
| Overalla | 1.06 | (0.31, 1.80)* | 9.21 | (−5.28, 23.70) | 0.50 | (−0.55, 1.56) | 1.71 | (−0.10, 3.51) |
| < 25b | 0.68 | (−0.74, 2.10) | −36.29 | (−79.51, 6.92) | 1.72 | (−0.56, 4.01) | 3.18 | (−1.11, 7.47) |
| 25–30b | 0.05 | (−1.17, 1.26) | −13.75 | (−36.17, 8.68) | −1.69 | (−3.55, 0.16) | −2.50 | (−5.86, 0.85) |
| > 30b | 1.77 | (0.58, 2.96)* | 31.32 | (12.52, 50.11)* | 1.76 | (0.23, 3.30) | 4.06 | (1.63, 6.49)* |
a
Main effect model without interaction terms. Adjusted for parity, maternal age, maternal education, maternal smoking status, and gestational age at sample collection (n = 391).
b
Stratified by mother's age at delivery. Model adjusted for parity, maternal education, maternal smoking status, and gestational age at sample collection (< 25 years of age: n =72; 25–30 years of age: n =151;> 30 years of age: n = 168).
*
p < 0.05.