Table 3.
Regression coefficients (β) for the association between maternal PFAS serum concentration (ng/mL) and communication development scores in daughters at 38 months of age overall and by mother's age at delivery (< 25 years of age, 25–30 years of age, > 30 years of age).
| Language | Intelligibility | Communicative | ||||
|---|---|---|---|---|---|---|
| β | 95% CI | β | 95% CI | β | 95% CI | |
| PFOS | ||||||
| Overalla | −0.29 | (−0.54, −0.05)* | −0.01 | (−0.01, 0.00)* | 0.00 | (−0.01, 0.01) |
| < 25b | −0.80 | (−1.74, 0.14) | 0.02 | (0.01, 0.03)* | 0.03 | (−0.02, 0.08) |
| 25–30b | −0.28 | (−0.72, 0.16) | 0.00 | (−0.02, 0.01) | −0.01 | (−0.02, 0.01) |
| > 30b | −0.30 | (−0.62, 0.01) | −0.01 | (−0.02, 0.00)* | 0.00 | (−0.02, 0.01) |
| PFOA | ||||||
| Overalla | −0.83 | (−2.21, 0.54) | −0.04 | (−0.08, −0.01)* | −0.02 | (−0.08, 0.04) |
| < 25b | −0.85 | (−5.60, 3.90) | 0.05 | (−0.01, 0.10) | 0.29 | (0.03, 0.54)* |
| 25–30b | −0.18 | (−2.48, 2.12) | −0.03 | (−0.10, 0.04) | −0.05 | (−0.14, 0.05) |
| > 30b | −1.52 | (−3.37, 0.33) | −0.06 | (−0.11, −0.01)* | −0.03 | (−0.11, 0.04) |
| PFHxS | ||||||
| Overalla | 0.17 | (−0.26, 0.61) | 0.00 | (−0.01, 0.01) | −0.01 | (−0.03, 0.01) |
| < 25b | −0.87 | (−6.28, 4.54) | −0.05 | (−0.11, 0.02) | −0.05 | (−0.35, 0.26) |
| 25–30b | 0.23 | (−0.41, 0.86) | 0.01 | (−0.01, 0.03) | −0.02 | (−0.05, 0.00) |
| > 30b | −0.20 | (−0.84, 0.45) | −0.01 | (−0.02, 0.01) | 0.01 | (−0.02, 0.03) |
| PFNA | ||||||
| Overall a | −1.52 | (−11.21, 8.16) | 0.02 | (−0.23, 0.27) | 0.39 | (−0.01, 0.79) |
| < 25b | −3.06 | (−20.75, 14.62) | 0.23 | (0.02, 0.44)* | 1.32 | (0.39, 2.25)* |
| 25–30b | −14.10 | (−27.71, −0.50)* | 0.01 | (−0.39, 0.40) | 0.54 | (−0.01, 1.08) |
| > 30b | 5.62 | (−15.20, 26.44) | −0.12 | (−0.68, 0.44) | −0.51 | (−1.34, 0.31) |
a
Main effect model without interaction terms. Adjusted for parity, maternal age, maternal education, maternal smoking status, gestational age at sample collection, and total maternal CCEI (n = 353).
b
Stratified by mother's age at delivery. Model adjusted for parity, maternal education, maternal smoking, gestational age at sample collection, and total maternal CCEI (< 25 years of age: n = 65; 25–30 years of age: n = 130; > 30 years of age: n = 158).
*
p < 0.05.