Table 2. Linear correlation analyze among prostaglandin E2 metabolite concentration and clinical parameters.

	Plasma-PGEM (pg/ml)		Urine-PGEM (ng/ml)
	r	P	r	P
Age (years)	-0.200	0.263	0.009	0.961
Onset age (years)	-0.290	0.101	-0.075	0.678
BMI(kg/m2)	0.143	0.505	0.093	0.657
SBP(mmHg)	0.164	0.396	0.138	0.476
eGFR	0.068	0.715	-0.019	0.918
QTc(sec)	-0.048	0.826	-0.116	0.580
Serum K+(mmol/L)	-0.146	0.418	-0.200	0.266
Serum Na+(mmol/L)	0.091	0.615	0.269	0.130
Serum Cl-(mmol/L)	-0.286	0.107	-0.409	0.018
Serum Mg2+(mmol/L)	0.032	0.860	-0.374	0.032
Serum Ca2+(mmol/L)	0.553	0.001	-0.059	0.746
Serum P(mmol/L)	0.086	0.632	-0.084	0.640
24h Urinary K+(mmol/d)	0.117	0.518	0.014	0.938
24h Urinary Na+(mmol/d)	0.061	0.735	0.349	0.050
24h Urinary Cl-(mmol/d)	0.006	0.972	0.300	0.102
24h Urinary Mg2+(mmol/d)	0.219	0.238	0.094	0.615
24h Urinary Ca2+(mmol/d)	-0.091	0.621	-0.443	0.013
24h Urinary P(mmol/d)	0.097	0.605	-0.035	0.853
Urinary Ca2+/Cr ratio	-0.369	0.045	-0.108	0.585
Blood gas cHCO3-(mmol/L)	0.098	0.589	0.428	0.013
Blood gas ABE(mmol/L)	0.119	0.508	0.544	0.001
Upright Renin(ng/ml/h)	-0.040	0.838	0.171	0.376
Upright Angiotensin II(pg/ml)	0.325	0.085	0.073	0.707
Upright Aldosterone(ng/dl)	-0.138	0.482	0.004	0.982
ΔClearance Cl in HCT test(ml/min)	0.130	0.619	-0.321	0.226

Abbreviations: ABE, actual base excess; eGFR, estimated glomerular filtration rate, ml/min/1.73m²; GS, Gitelman syndrome; SBP, systolic blood pressure; PGEM, prostaglandin E2 metabolite; ΔClearance Cl, the absolute increases in the chloride learance rate; HCT, hydrochlorothiazide