Table 2. Regression coefficients, ORs, and 95% CIs of the final combined model* for predicting SPTD at <32 weeks of gestation.
Predictor | Beta-coefficient | SE | OR (95% CI) | P-value |
---|---|---|---|---|
Cervical dilatation (cm) | 0.943 | 0.262 | 2.56 (1.53–4.29) | <0.001 |
Cervicovaginal fluid VDBP (μg/mL) | 0.875 | 0.382 | 2.39 (1.13–5.07) | 0.022 |
Use of corticosteroid | 1.866 | 0.817 | 6.46 (1.30–32.03) | 0.022 |
Constant | -3.552 | 0.937 | 0.029 | <0.001 |
OR, odds ratio; CI, confidence interval; SPTD, spontaneous preterm delivery; SE, standard error; VDBP, vitamin D binding protein; TIMP, tissue inhibitor of metalloproteinases; DKK, Dickkopf; CVF, cervicovaginal fluid; CRP, C-reactive protein. The formula that was generated to predict SPTD at <32 weeks was as follows: Y = logₑ (Z) = -3.552 + 0.943 × [cervical dilatation (in cm)] + 0.875 × [cervicovaginal fluid VDBP (in μg/mL)] + 1.866 × (1 for use of corticosteroid, 0 for non-use of corticosteroid). Z = eY and risk (%) = [(Z / (1+Z)] × 100.
*Final model resulting from a forward regression analysis including the following predictive parameters: VDBP, TIMP-1, and DKK3 in the CVF, serum CRP, cervical dilatation, vaginal progesterone therapy, and use of corticosteroids.