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. 2017 Jul 10;12(7):e0181075. doi: 10.1371/journal.pone.0181075

Fig 1. Effects of CGMP on mouse intestinal morphological injury index scoring.

Fig 1

N: normal control group; M: OXZ-model group; S: SASP-treated group; C1: CGMP group 1 (50 mg/kg bw•d) and C2: CGMP group 2 (200 mg/kg bw•d). Each mouse in the five groups was anatomized: its abdominal cavity was opened, its intestines were separated and the stool was removed. Changes in intestinal morphology were observed, and pathologically altered sites were scored. The scoring criteria were divided into six grades according to the severity of injury in the intestinal mucosa. Grades above the 5th grade indicate two or more sites with serious ulceration and/or inflammation or one site where ulceration/inflammation was observed. When injured sections longer than 1 cm in the intestine on the vertical axis were observed, 1 scoring point was added; the highest scoring point was 10. Within the figure,* indicates a significant difference compared with the normal control group (P < 0.05); ** indicates an extremely significant difference compared with the normal control group (P < 0.01); + indicates a significant difference compared with the model control group (P < 0.05); and ++ indicates an extremely significant difference compared with the model control group (P < 0.01).