Fig 3. Associations of baseline BK and hyp3-BK(1–8) with change in cortical interstitial fractional volume [Vv(Int/cortex)] in the 66 participants assigned to placebo, the 63 participants assigned to enalapril, and the 60 participants assigned to losartan in RASS.

Residuals were computed by regressing each of the variables on baseline age, duration of diabetes, HbA1c, mean arterial pressure, treatment assignment and baseline Vv(Int/cortex). Residuals are plotted on logarithmic scales. Values above the dashed lines reflect an increase in Vv(Int/cortex) and those below the lines a decrease over 5 years.