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. 1980 Jan;27(1):113–117. doi: 10.1128/iai.27.1.113-117.1980

Serum antibodies to herpes simplex virus type 1 during active oral herpes infection.

J J Ratner, K O Smith
PMCID: PMC550732  PMID: 6244224

Abstract

Subjects with oral herpes lesions at the time of serum sampling had higher-efficiency antibody (higher proportion of neutralizing antibody as determined by plaque reduction, compared with total antibody as detected by radioimmunoassay) to herpes simplex virus type 1 (HSV-1) than did subjects with no lesions at the time of serum sampling. These higher-efficiency sera also had higher antibody titers to structural components of herpes simplex virus type 1 than did the low-efficiency sera. Absorption of high- and low-efficiency sera with purified herpes simplex virus type 1 particles removed all neutralizing antibody but not all antibody detected by radioimmunoassay. High-efficiency serum was depleted of more antibody to particulate antigen that was the low-efficiency serum, indicating that the high-efficiency serum contained a higher proportion of antibody to the virus particle.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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