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. Author manuscript; available in PMC: 2017 Jul 12.
Published in final edited form as: Chem Res Toxicol. 2012 Feb 6;25(2):326–336. doi: 10.1021/tx200376e

Figure 1. Oxidative DNA-protein crosslink can form hydantion rings.

Figure 1

When oxidized, DNAs and proteins can crosslink due to the generation of strong electrophiles. DNA-protein crosslinks are known to occur in cells with several structures as products. Proteins are known to crosslink via tyrosyl and lysyl groups, while guanine, thymidine, and abasic sites in DNA undergo the crosslinking reaction.