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. Author manuscript; available in PMC: 2017 Jul 12.
Published in final edited form as: Chem Res Toxicol. 2012 Feb 6;25(2):326–336. doi: 10.1021/tx200376e

Figure 5. Guanine content correlates with crosslink yield.

Figure 5

(Left) Ethidium bromide stained gel comparing the crosslinking yield of three 27-nucleotide DNA strands. The first strand is a mixed sequence. The second and third strands lack thymine and guanine, respectively. Loss of guanine leads to loss of product. (Right) Guanines from the 27-mer DNA model were sequentially replaced by adenine. Removal of guanines occurred from the 5’-end toward the 3’-end. The yield decreases as less guanines are present indicating that the crosslink product is likely between guanine and the protein.