Fig 7. Profiles of chemokines of mononuclear-macrophages and neutrophils in serum samples from L. interrogans-infected mice and leptospirosis patients.

(A) Detection results of the mouse and human chemokines of mononuclear-macrophages and neutrophils in sera from C3H/HeJ mice during infection with L. interrogans strain Lai, determined by chemokine detection microarrays for the indicated infection times. The spots within red frames indicate the mononuclear-macrophage chemokines, the spots within blue frames indicate the neutrophil chemokines. (B) Statistical summary of the chemokine profile in the serum samples from L. interrogans-infected mice. Statistical data from the microarray detection such as shown in A. Bars show the means ± SD of five independent serum samples. The means of chemokine levels in the serum samples from five mice without infection were set as 1.0. The bars within red frames indicate the mononuclear-macrophage chemokines and the bars within blue frames indicate the neutrophil chemokines. *: p<0.05 vs the chemokine levels in the serum samples from mice without infection. (C) Statistical summary of the chemokine profiles in the serum samples from leptospirosis patients. Statistical data from the microarray detection such as shown in A. Bars show the means ± SD of five patients. The means of chemokine levels in the serum samples from five healthy individuals were set as 1.0. The bars within red frames indicate the mononuclear-macrophage chemokines and the bars within blue frames indicate the neutrophil chemokines. *: p<0.05 vs the chemokine levels in the serum samples from five healthy individuals.