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. 2017 Jul 12;15(7):e2000737. doi: 10.1371/journal.pbio.2000737

Fig 4. Dividing an embryo in half at 2-, 4-, or 8-cell stage results in a successful blastocyst of half the size.

Fig 4

(a) Screenshots from a simulation with halving at the 8-cell stage (see S8 Movie). (b) Quantification of the developmental success in in silico blastocysts at embryonic day (E) 4.5 after it has been cut in half (notations and color coding are the same as in Fig 3b). (c) The fraction of inner cell mass (ICM) cells to the total number of cells at E4.5 in the 7 different types of embryos. (d) The fraction of epiblast (EPI) cells to ICM cells at E4.5. Both in (c) and (d), the number for unperturbed embryos is in black, and those that were divided in half are shown in gray. The simulation data can be found in S1 Data.