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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Biol Psychiatry. 2016 May 27;80(9):682–690. doi: 10.1016/j.biopsych.2016.05.015

Figure 3. The effects of high- and low-frequency DBS on c-fos expression in prefrontal, striatal, and amygdala regions.

Figure 3

(A) Diagram showing a representative coronal section of DBS electrode placements in the dorsal-VS, for both high-frequency (HF) and low-frequency (LF) groups. (B–C) Both high and low frequency DBS increased c-fos immunoreactivity in IL, whereas neither affected NAc subregions. (D) Only low frequency DBS increased c-fos labeling in the amygdala (BA and CeM). Abbreviations: PL= prelimbic cortex; IL= infralimbic cortex; core= nucleus accumbens core; shell= nucleus accumbens shell; BA= basal nucleus of the amygdala; CeL= lateral portion of the central nucleus of the amygdala; CeM= medial portion of the central nucleus of the amygdala. Sham: n= 6; high frequency DBS: n= 4; low frequency DBS: n= 5. Data represented as mean SEM. *p<0.05; **p<0.01.