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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Free Radic Biol Med. 2017 Apr 30;108:741–749. doi: 10.1016/j.freeradbiomed.2017.04.367

Fig. 2.

Fig. 2

Intracellular competition between glutathione (GSH), reduced PDI (PDI-SH) and other protein thiols (P-SH) for a membrane-permeant inhibitor, I. Panels A and B represent reversible and irreversible thiol-directed inhibition, respectively. PDI is likely to be largely reduced intracellularly.