Table 2.
Mycobactericidal effects of aldehyde-based and oxidizing high-level disinfectants against GTA-susceptible and GTA-resistant Mycobacterium isolates in carrier tests.
| Product tested |
Mmas CIP 108297 (GTAS) |
Mmas CRM-0270 (GTAS) |
Mmas CRM-0019 (GTAR) |
Mch ATCC 35752 (GTAS) |
Mch 9917 (GTAR) |
Mch Harefield (GTAR) |
Mch Epping (GTAR) |
M. bovis BCG (Pasteur) (GTAS) |
M. avium 104 (GTAS) |
M. terrae ATCC 15755 (GTAS) |
|---|---|---|---|---|---|---|---|---|---|---|
| Cidex® (1.5% GTA) 25°C | ||||||||||
| 0 min | 7.55±0.03 | 7.30±0.06 | 7.52±0.00 | 7.59±0.05 | 6.91±0.11 | 7.34±0.01 | 7.44±0.11 | nd | nd | nd |
| 45 min | 0 | 0 | 6.14±0.06 | 0 | 4.59±0.28 | 3.74±0.00 | 5.77±1.3 | nd | nd | nd |
| Aldahol® (1.8% GTA) 20°C | ||||||||||
| 0 min | 7.55±0.03 | 7.30±0.06 | 7.52±0.00 | 7.59±0.05 | 6.91±0.11 | 7.38±0.12 | 7.44±0.11 | nd | nd | nd |
| 20 min | 0 | 0 | 0 | 0 | 4.57±0.17 | 2.96±0.09 | 5.94±0.35 | nd | nd | nd |
| 15% Isopropanol 25°C | ||||||||||
| 0 min | 7.55±0.03 | 7.30±0.06 | nd | 7.59±0.05 | 6.91±0.11 | 7.38±0.12 | 7.44±0.11 | nd | 8.43 | nd |
| 20 min | 7.67±0.34 | 7.77±0.00 | nd | 7.91±0.05 | 6.89±0.02 | 7.45±0.14 | 7.52±0.17 | nd | 6.33±0.00 | nd |
| Cidex® OPA (0.3% OPA) 25°C | ||||||||||
| 0 min | 7.55±0.03 | 7.30±.06 | 7.52±0.00 | 7.59±0.05 | 6.91±0.11 | 7.38±0.12 | 7.44±0.11 | nd | nd | nd |
| 5 min | 0 | 0 | 0 | 0 | 0 | 0 | 0 | nd | nd | nd |
| Reliance™ DG 50°C | ||||||||||
| 0 min | 7.45±0.01 | 7.59±0.06 | 8.31±0.00 | 7.63±0.03 | 6.49±0.00 | 7.63±0.06 | 7.46±0.00 | nd | 8.43±0.03 | 7.00±0.08 |
| 6 min | 0 | 0 | 0 | 0 | 0 | 0 | 0 | nd | 0 | 0 |
| S40™ 50°C | ||||||||||
| 0 min | 7.45±0.01 | 7.59±0.06 | 8.31±0.00 | 7.63±0.03 | 6.49±0.00 | 7.63±0.06 | 7.46±0.00 | nd | 8.43±0.03 | 7.00±0.08 |
| 6 min | 0 | 0 | 0 | 0 | 0 | 0 | 0 | nd | 0 | 0 |
| Resert™ XL 25°C | ||||||||||
| 0 min | 7.55±0.03 | 7.30±0.06 | nd | 7.59±0.05 | 6.91±0.11 | 7.38±0.12 | 7.44±0.11 | nd | nd | nd |
| 8 min | 0 | 0 | nd | 0 | 0 | 0 | 0 | nd | nd | nd |
See Table 1 for legend. Control carrier tests using the GTA-susceptible isolate, M. massiliense CIP 108297, confirmed the neutralizing efficacy of the neutralizing broth with each disinfectant product. The detection limit of the carrier disk tests is 1 CFU.