Table 2.

Risk-of-Bias of the Included Study

Davidson et al 2010
Characteristic	Details
Random sequence generation: (Selection bias)	Low Risk.“Participants were randomized to either the intervention or control group by means of a computer- generated program”
Allocation concealment: (Selection Bias)	Low Risk.“The randomization technique was blinded to the investigators until the close of the study”
Blinding: (Performance bias and Detection bias)	High risk. Neither the participants nor investigators were blinded to the interventions at allocation or during outcome assessment
Selective reporting: (Reporting bias)	Low Risk.“All pre-selected outcome metrics were reported”
Intention-to-treat analysis?	Low Risk. “All analyses were carried out on an intention-to- treat basis”
Incomplete outcome data?	Low Risk. “No participants were lost to follow-up”
Group balanced at baseline?	High risk. “Significantly greater proportion of people in the intervention group were taking spironolactone at baseline”
Groups received same intervention?	Low risk. The groups were treated in a similar fashion apart from the intervention