Table 1.
Summary of the demographic and clinical findings and its confocal and histological diagnosis.
| Case no. | Gender | Ethnicity | Concomitant malignancy | Date of RCM imaging | Treatments for EMPD prior to RCM | Clinical description and location | Margin or center of lesion | RCM diagnosis | Histopathology diagnosis |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Male | Caucasian | None | April, 2016 | Surgery (2014) | Erythematous macule, anterior perineum | Margin | Negative | Negative |
| Erythematous macule, right perineum | Margin | Negative | Negative | ||||||
| Erythematous macule, posterior perineum | Margin | EMPD | EMPD | ||||||
| 2 | Female | Caucasian | None | June, 2014 | Surgery (2014) | Erythematous macule, mons pubis | Margin | EMPD | EMPD |
| November, 2014 | Recurrent EMPD treated with imiquimod (2014) | Approximate area of previous biopsy, mons pubis | Margin | Negative | EMPD | ||||
| Erythematous patch, labia minora | Margin | EMPD | EMPD | ||||||
| 3 | Male | Caucasian | None | June, 2015 | Radiotherapy (2013) | Erythematous patch, left anterior scrotum | Margin | Negative | Negative |
| Erythematous patch, left inferior scrotum | Center | EMPD | EMPD | ||||||
| Erythematous patch, left mid inguinal crease | Margin | Negative | Negative | ||||||
| Erythematous patch, anterior perineum | Margin | Negative | Negative | ||||||
| Erythematous patch, posterior perineum | Margin | Negative | Negative | ||||||
| Erythematous patch, right lateral scrotum | Margin | Negative | Negative | ||||||
| January, 2016 | Recurrent EMPD treated with oral HER2-TKI (2015) | Erythematous patch, left inferior scrotum next to biopsy scar | Margin | Negative | EMPD | ||||
| Erythaematous patch, left inferior scrotum below biopsy scar | Margin | Negative | EMPD | ||||||
| 4 | Male | Caucasian | Papillary renal cell carcinoma | January, 2016 | Surgery (2011), residual EMPD treated with RT (2011) | Erythematous patch, penile shaft | Margin | EMPD | EMPD |
| Erythematous patch, left scrotum | Center | EMPD | EMPD | ||||||
| 5 | Male | Caucasian | None | April, 2016 | WLE (January, 2015); Mohs surgery (October, 2015) | Erythematous patch, right anterior scrotum | Margin | EMPD | EMPD |
| Erythematous patch, left anterior scrotal margin | Margin | EMPD | EMPD | ||||||
| Erythematous patch, center of scrotum | Center | EMPD | EMPD | ||||||
| Eroded erythematous patch, right posterior scrotum | Center | Negative | Negative | ||||||
| Erythematous macule, outside right border of the inguinal crease | Margin | Negative | Negative | ||||||
| Erythematous macule, margin of previous graft in the right ventral penile shaft | Margin | Negative | Negative |
Abbreviations: EMPD, extramammary Paget disease; HER2-TKI, HER2 tyrosine kinase inhibitor; RT, radiotherapy; WLE: wide local excision, RCM, reflectance confocal microscopy