Table 1.
Patient characteristics at initiation of study treatment | N (%) |
---|---|
| |
Male sex | 11 (85%) |
| |
Median age, years (range) | 68 (44–75) |
| |
Prior chemoimmunotherapy | 8 (62%) |
| |
Median prior treatments (range) | 1 (1–2) |
• Prior purine analogue | 9 (69%) |
• Prior rituximab | 10 (77%) |
• Prior alemtuzumab | 5 (38%) |
• Chlorambucil | 1 (7.7%) |
| |
Rai stage, median (range) | 3 (1–4) |
• Rai 1–2 | 5 (38%) |
• Rai 3–4 | 8 (61%) |
| |
CLL FISH | |
• 11q- | 4 (31%) |
• Trisomy 12 | 2 (15%) |
• 13q- | 3 (23%) |
• Normal | 2 (15%) |
• Other | 2 (15%) |
| |
Median β-2 microglobulin (range) | 7.11 (3.4–9.9) |
| |
IgHV status | |
• Unmutated | 10 (77%) |
• Mutated | 1 (7.7%) |
• Not done | 2 (15%) |
| |
ZAP-70 expression | |
• Positive | 8 (62%) |
• Negative | 3 (23%) |
• Not done | 2 (15%) |
| |
CD38 expression | |
• Positive | 8 (46%) |
• Negative | 5 (23%) |
| |
Median ALC (×103/uL) (range) | 43.9 (1.5 – 306.3) |