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. 2017 Aug;16(8):601–609. doi: 10.1016/S1474-4422(17)30124-2

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© 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Association between baseline NfL concentration in plasma and progression to manifest Huntington's disease in HTT mutation carriers who were premanifest at baseline

(A) NfL concentration in plasma at baseline by disease progression status at 3 years. Boxes show first and third quartiles, the central band shows the median, and the whiskers show data within 1·5 IQR of the median. The dots represent outliers. (B) Kaplan-Meier plot showing longitudinal survival in the premanifest state among HTT mutation carriers with NfL concentrations in plasma greater or less than the median. The Cox proportional hazards model is the more sensitive of the two models presented here.