Table 2.
Frequency of volumetric laser endomicroscopy imaging features in histologic subgroups n (%)
| IMC/HGD (n = 1) | LGD (n = 6) | NDBE (n = 6) | Inflamed cardia (n = 9) | No diagnostic abnormality (n = 12) | Neoplastic1 (n = 7) | Non-neoplastic2 (n = 27) | P-value3 | |
| Gastric rugae | 1 (100) | 6 (100) | 6 (100) | 9 (100) | 12 (100) | 7 (100) | 27 (100) | NS |
| Gastric pit architecture | 1 (100) | 6 (100) | 6 (100) | 9 (100) | 12 (100) | 7 (100) | 27 (100) | NS |
| Poor penetration | 1 (100) | 6 (100) | 6 (100) | 9 (100) | 12 (100) | 7 (100) | 27 (100) | NS |
| Loss of normal gastric pit architecture | 1 (100) | 6 (100) | 5 (83) | 8 (89) | 7 (58) | 7 (100) | 20 (74) | NS |
| Irregular surface | 1 (100) | 6 (100) | 2 (33) | 1 (11) | 2 (20) | 7 (100) | 5 (19) | < 0.0001 |
| Heterogeneous scattering | 1 (100) | 5 (83) | 5 (83) | 6 (67) | 3 (25) | 6 (86) | 14 (52) | < 0.005 |
| Epithelial glands | 1 (100) | 6 (100) | 6 (100) | 9 (100) | 12 (100) | 7 (100) | 27 (100) | NS |
| Anomalous glands | 1 (100) | 6 (100) | 5 (83) | 6 (67) | 5 (42) | 7 (100) | 16 (59) | < 0.05 |
1
Neoplastic: HGD + IMC;
2
Non-neoplastic: NDBE + IGC + NL;
3
P value: Neoplastic vs non-neoplastic. IMC: Intramucosal carcinoma; HGD: High-grade dysplasia; LGD: Low grade dysplasia; NDBE: Barrett’s without no dysplasia; IGC: Inflamed gastric cardia; NL: Normal mucosa; NS: Not significant.